Descrizione Clinica
For nails and hair Projaluseon 30cpr
PROJALUSEON
Description
Food supplement for the aesthetics and health of skin, hair and mucous membranes, for better functionality of the osteo-artro-musclelegamentose apparatus and a global anti-aging action. Projaluseon is a complete and innovative multicomponent nutraceutical based on hyaluronic acid, carnosine, methylsulphonylmethane (MSM) and zinc. Based on international literature is indicated:
-In skin rehydration and against skin aging (wrinkles, reduced elasticity, dryness, chrono/photo- aging, hypoxane) (1-6).
-In joint degenerations: arthrosis/artrites and joint knee, hip, elbow, shoulder and ankle (7-10).
-In the alopecia or in other dysfunctions of the skin outbuildings (1, 6, 11-13).
- In the healing processes of skin ulcers, surgical wounds and burns (1, 12-15).
-In the postmenopausal vaginal atrophy and other pathologies of soft tissues (tendini, vocal cords, cornea, vitreous body, oral mucosa) (1, 12, 13, 16, 17).
Projaluseon is a unique supplement for composition and doses:
-High-dose hyaluronic acid (100 mg), vegetable extraction and high molecular weight (1,600 kdalton), which improve its boavailability.
-Carnosine at medium-high doses with strong anti-glycation action (so against stiffness and hypoelasticity of collagen, elastin and connective tissue in general), antioxidant and basic tissue action.
-MSM that synergistically complements the action of the Hyaluronic Acid.
Zinc, in the form of zinc gluconate to 14% in dose of 10 mg contributes to the maintenance of normal skin, nails and bones.
-Compresses acid-resistant with increased bioavailability.
Projaluseon does not contain gluten, it is GMO Free and Vegan OK.
Property
Hyaluronic acid: high molecular weight (1,600 kdalton), with moisturizing and elasticizing properties of skin, mucosa, allecolations and conneive in general.
Carnosine: dipeptide by proven anti-glycation properties, against AGEs typical of skin aging, but also powerful antioxidant and basic tissues, then complete anti-aging agent.
Metilsulphonylmethane (MSM): based on sulphur that stabilizes protein ties, toning skin and hair and favoring cartilage synthesis.
Zinc: mineral that contributes to the maintenance of normal skin, hair, nails and bones.
Ingredients
L-carnosine, methylsulphonylmethane (MSM), hyaluronic acid sodium salt, microcrystalline cellulose; gelling agent: hydroxypropylmethylcellulose; antiagglomerant: colloidal silica; zinc gluconate: antiagglomerating: magnesium stearate vegetable.
Without gluten.
Nutritional characteristics
Mode of use
1-2 tablets per day, possibly during breakfast and/or lunch; it is recommended to drink some glass of water in the 3-4 hours after taking.
Warnings
Do not use during pregnancy. The product should be used in a varied and balanced diet following a healthy lifestyle. Do not exceed the recommended daily doses. Keep out of reach of children under 3 years.
Conservation
Store the product safe from light, in a cool and dry place.
Validity of whole packaging: 36 months.
Format
Pack of 30 acid-resistant tablets of 800 mg in blister.
Net weight: 24 g.
Bibliography
1) Hyaluronic acid. Key molecules in skin aging. Papakonstantinou E, Roth M, Karakiulakis G Dermato-Endocrinology 2012 4:3, 253-258.
2) Ingested hyaluronan moisturizes dry skin. Kawada C, Yoshida T, Yoshida H et al Nutr J. 2014 Jul 11;13:70.
3) Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. Kawada C, Yoshida T, Yoshida H et al J Clin Biochem Nutr. 2015 Jan;56(1):66-73.
4) Skin beautification with oral non-hydrolized versions of carnosine and carcinine: effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. Babizhayev MA, Deyev AI, Savel'yeva EL et al J Dermatolog Treat. 2012 Oct;23(5):345-84 5) Carnosine and the processes of ageing. Hipkiss AR, Baye E, de Courten B Maturitas. 2016 Jun 22. 30134-7.
6) Carnosine: a versatile antioxidant and antiglycating agent Reddy VP, Garrett MR, Perry G et al Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
7) Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo- Controlled Study over a 12-Month Period. Toshiyuki T,Satoshi S,Toshihide S et al Scientific World Journal. 2012; 167928.
8) The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Nelson FR, Zvirbulis RA, Zonca B et al Rheumatol Int. 2015 Jan;35(1):43-52.
9) Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Brien S, Prescott P, Lewith G Evid Based Complement Alternat Med. 2011; 528403.
10) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study Debbi EM, Agar G, Fichman G et al Complement Altern Med. 2011; 11: 50.
11) A Nutritional Supplement Formulated with Peptides, Lipids, Collagen and Hyaluronic Acid Optimizes Key Aspects of Physical Appearance in Nails, Hair and Skin Yagoda MR, Gans And J Nutr Food Sci 2014, S5.
12) The biological role of carnosine and its possible applications in medicines Budzen S, Rymaszewska J. Adv Clin Exp Med. 2013 Sep-Oct;22(5):739-44.
13) Carnosine: its properties, functions and potential therapeutic applications Quinn PJ, Boldyrev AA, Formazuyk VE Mol Aspects Med 1992, 13(5): 379-444.
14) Action of carnosine on wound healing Nagai K et al. Surgery 1986, 100(5):815-821.
15) Dietary Peptides Improve Wound Healing Following Surgery Roberts P, Ward K,Santamauro J et al Nutrition , 3, 1998, 3: 266-269.
16) The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Ekin M, Yasar L, Savan K et al Arch Gynecol Obstet. 2011 Mar;283(3):539- 43.
17) Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis. La Galia T, Micali A, Puzzolo D et al International Journal of Clinical Medicine, 2014, 5: 617-624.
Food supplement for the aesthetics and health of skin, hair and mucous membranes, for better functionality of the osteo-artro-musclelegamentose apparatus and a global anti-aging action. Projaluseon is a complete and innovative multicomponent nutraceutical based on hyaluronic acid, carnosine, methylsulphonylmethane (MSM) and zinc. Based on international literature is indicated:
-In skin rehydration and against skin aging (wrinkles, reduced elasticity, dryness, chrono/photo- aging, hypoxane) (1-6).
-In joint degenerations: arthrosis/artrites and joint knee, hip, elbow, shoulder and ankle (7-10).
-In the alopecia or in other dysfunctions of the skin outbuildings (1, 6, 11-13).
- In the healing processes of skin ulcers, surgical wounds and burns (1, 12-15).
-In the postmenopausal vaginal atrophy and other pathologies of soft tissues (tendini, vocal cords, cornea, vitreous body, oral mucosa) (1, 12, 13, 16, 17).
Projaluseon is a unique supplement for composition and doses:
-High-dose hyaluronic acid (100 mg), vegetable extraction and high molecular weight (1,600 kdalton), which improve its boavailability.
-Carnosine at medium-high doses with strong anti-glycation action (so against stiffness and hypoelasticity of collagen, elastin and connective tissue in general), antioxidant and basic tissue action.
-MSM that synergistically complements the action of the Hyaluronic Acid.
Zinc, in the form of zinc gluconate to 14% in dose of 10 mg contributes to the maintenance of normal skin, nails and bones.
-Compresses acid-resistant with increased bioavailability.
Projaluseon does not contain gluten, it is GMO Free and Vegan OK.
Property
Hyaluronic acid: high molecular weight (1,600 kdalton), with moisturizing and elasticizing properties of skin, mucosa, allecolations and conneive in general.
Carnosine: dipeptide by proven anti-glycation properties, against AGEs typical of skin aging, but also powerful antioxidant and basic tissues, then complete anti-aging agent.
Metilsulphonylmethane (MSM): based on sulphur that stabilizes protein ties, toning skin and hair and favoring cartilage synthesis.
Zinc: mineral that contributes to the maintenance of normal skin, hair, nails and bones.
Ingredients
L-carnosine, methylsulphonylmethane (MSM), hyaluronic acid sodium salt, microcrystalline cellulose; gelling agent: hydroxypropylmethylcellulose; antiagglomerant: colloidal silica; zinc gluconate: antiagglomerating: magnesium stearate vegetable.
Without gluten.
Nutritional characteristics
| Average values | For 1 cpr | For 2 cpr |
| Hyaluronic acid sodium salt | 11,2 mg | 228,4 mg |
| corresponding to Hyaluronic Acid | 100 mg | 200 mg |
| L-Carnosine | 250 mg | 500 mg |
| Metilsulphonylmethane (MSM) | 200 mg | 400 mg |
| Zinc gluconate 14% | 10 mg | 20 mg |
Mode of use
1-2 tablets per day, possibly during breakfast and/or lunch; it is recommended to drink some glass of water in the 3-4 hours after taking.
Warnings
Do not use during pregnancy. The product should be used in a varied and balanced diet following a healthy lifestyle. Do not exceed the recommended daily doses. Keep out of reach of children under 3 years.
Conservation
Store the product safe from light, in a cool and dry place.
Validity of whole packaging: 36 months.
Format
Pack of 30 acid-resistant tablets of 800 mg in blister.
Net weight: 24 g.
Bibliography
1) Hyaluronic acid. Key molecules in skin aging. Papakonstantinou E, Roth M, Karakiulakis G Dermato-Endocrinology 2012 4:3, 253-258.
2) Ingested hyaluronan moisturizes dry skin. Kawada C, Yoshida T, Yoshida H et al Nutr J. 2014 Jul 11;13:70.
3) Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study. Kawada C, Yoshida T, Yoshida H et al J Clin Biochem Nutr. 2015 Jan;56(1):66-73.
4) Skin beautification with oral non-hydrolized versions of carnosine and carcinine: effective therapeutic management and cosmetic skincare solutions against oxidative glycation and free-radical production as a causal mechanism of diabetic complications and skin aging. Babizhayev MA, Deyev AI, Savel'yeva EL et al J Dermatolog Treat. 2012 Oct;23(5):345-84 5) Carnosine and the processes of ageing. Hipkiss AR, Baye E, de Courten B Maturitas. 2016 Jun 22. 30134-7.
6) Carnosine: a versatile antioxidant and antiglycating agent Reddy VP, Garrett MR, Perry G et al Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
7) Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo- Controlled Study over a 12-Month Period. Toshiyuki T,Satoshi S,Toshihide S et al Scientific World Journal. 2012; 167928.
8) The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Nelson FR, Zvirbulis RA, Zonca B et al Rheumatol Int. 2015 Jan;35(1):43-52.
9) Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee. Brien S, Prescott P, Lewith G Evid Based Complement Alternat Med. 2011; 528403.
10) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study Debbi EM, Agar G, Fichman G et al Complement Altern Med. 2011; 11: 50.
11) A Nutritional Supplement Formulated with Peptides, Lipids, Collagen and Hyaluronic Acid Optimizes Key Aspects of Physical Appearance in Nails, Hair and Skin Yagoda MR, Gans And J Nutr Food Sci 2014, S5.
12) The biological role of carnosine and its possible applications in medicines Budzen S, Rymaszewska J. Adv Clin Exp Med. 2013 Sep-Oct;22(5):739-44.
13) Carnosine: its properties, functions and potential therapeutic applications Quinn PJ, Boldyrev AA, Formazuyk VE Mol Aspects Med 1992, 13(5): 379-444.
14) Action of carnosine on wound healing Nagai K et al. Surgery 1986, 100(5):815-821.
15) Dietary Peptides Improve Wound Healing Following Surgery Roberts P, Ward K,Santamauro J et al Nutrition , 3, 1998, 3: 266-269.
16) The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: a randomized controlled trial. Ekin M, Yasar L, Savan K et al Arch Gynecol Obstet. 2011 Mar;283(3):539- 43.
17) Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis. La Galia T, Micali A, Puzzolo D et al International Journal of Clinical Medicine, 2014, 5: 617-624.
